Webb13 feb. 2024 · 结果发亚基的his88在野生型中的pka是4.92,在突变体是5.36,这导致ef螺旋运动到ef环区上,并且通过结合自由能的计算发现v30attr中ac亚基之间的结合自由能较低,这说明v30attr两个亚基的结合更加紧致,四聚体结构更加稳定。 Webb"Only I can change my life. No one else can do it for me" ~Carol Burnett
HiSo88 - รวมข่าวเกี่ยวกับ "HiSo88" เรื่องราวของHiSo88
Webb1 dec. 2016 · In addition, His88′ (where ′ indicates residues on the neighboring subunit within a dimer, same as below) forms a stacking interaction with Arg116, stabilizing the Asp48-Arg116 dyad (Fig. 4A). Consistent with these observations, substituting Asp48, His88, or Arg116 in PtLCIB4 (and the corresponding Asp309, His349, and Arg377 in … Webb1 apr. 2015 · Histidine 88 (His88) is an amino acid in TTR that is important for the stability of the TTR tetramer. A large hydrogen-bond network is formed by Thr75, Trp79, His88, … philip eisenberg locke lord
His74 conservation in the bilin reductase PcyA family reflects an ...
WebbHis74 is H-bonded via a bridging water molecule to His88 suggest-97. ing that His74 plays a direct role in His88 re-protonation. More-98. over, the buried water between His88 and His74 is present. 99. whether or not substrate is bound. Interestingly, exchange of. 100. His74 with other residues only capable of hydrogen bonding. 101 WebbHis88 can accept an H-bond from H 3 O + but cannot decrease pK a (H 3 O +) to pK a (Nϵ His88) because of the absence of a negative charge. The nearest acidic residue Glu76 … WebbIn models M3 and M4 the substrate binds in the same way as in M1 and M2, respectively, but the side chain of the His88 residue is no longer coordinated to the metal, but is instead rotated away and exposed to the solvent. The hypothesis that the His88 residue might dissociate from the metal upon substrate binding is based on several clues. philip ehrhorn