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WebMar 1, 2003 · Abstract. Neurofilament light chain polypeptide (NEFL) is one of the most abundant cytoskeletal components of the neuron. Mutations in the NEFL gene were recently reported as a cause for autosomal dominant Charcot–Marie–Tooth type 2E (CMT2E) linked to chromosome 8p21. In order to investigate the frequency and phenotypic … WebNeurofilament light polypeptide, also known as neurofilament light chain, abbreviated to NF-L or Nfl and with the HGNC name NEFL is a member of the intermediate filament protein family. This protein family consists of over 50 human proteins divided into 5 major classes, the Class I and II keratins, Class III vimentin, GFAP, desmin and the others, the Class IV … WebThe NEFL gene encodes the neurofilament light polypeptide, a subunit that forms type IV intermediate filament heteropolymers, which are a major component of the neuronal cytoskeleton (summary by Agrawal et al., 2014 ). Cytoplasmic intermediate filaments (IF) can be divided into 5 subclasses based on their biochemical properties, immunologic ... bricks yellow