2024 Phenome-wide association study

Phenome-wide association study

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WebJul 11, 2024 · A phenome-wide association study of PCSK9 loss-of-function (LoF) variants has the potential to predict adverse effects of PCSK9 inhibition and generate hypotheses about unknown beneficial effects. Comparing carriers of such LoF variants with noncarriers can simulate the effects of blocking the corresponding protein. WebThe genome-wide association study (GWAS) approach has well-developed methods and relatively straight-forward methodologies; however, the bigger picture of the impact of genetic architecture on phenotypic outcome still remains to be elucidated even with an ever-growing number of GWAS performed.

Phenome-Wide Association Studies as a Tool to Advance …

WebOct 6, 2024 · Phenome-wide association studies. Phenome-wide association studies (PheWAS) examine and identify associations between a large number of disease phenotypes and a specific genotype or phenotype of interest. Here we used the PheWAS approach to identify associations between 1,703 possible disease phenotypes in the HNP … WebOct 6, 2024 · Phenome-wide association studies. p-values ranging from p = 8.1 × 10 –32 to p = 3.91 × 10 –18. These values are reported in Supplementary Table 1, with the strongest associations (p < 1 × 10 –20) shown in Table 4. TABLE 4. Most significant associations of the dose-response phenome-wide association study. Phenotype Description: primus in calgary

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WebJan 19, 2024 · Phenome-wide association study of the major histocompatibility complex region in the Korean population identifies novel association signals. Chanwoo Kim, Young … WebDec 11, 2024 · Using data from approximately 100,000 participants in the UK Biobank, actigraphy-derived measures of physical activity, sleep, and diurnal rhythms were associated in exploration and validation cohorts with a full phenome-wide set of … WebFeb 23, 2024 · The phenome-wide association study Open in figure viewer PowerPoint Once a curated medical phenome is in place, investigators can use a wide variety of input … primus infarmed

A phenome-wide association study of genetically …

Methodology in phenome-wide association studies: a systematic review

WebMar 29, 2024 · As a phenome-wide investigation, this study examined many binary disease outcomes. For outcomes of primary and sensitivity analyses, we used genome-wide association summary statistics from the European ancestry subset of UKB. The focus on European ancestry was needed to reduce heterogeneity and maximize statistical power. WebMethods and results: A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry participants (13 765 cases) was performed. Seventeen loci were associated with AS at P ≤ 5 × 10-8, of which 15 replicated in an independent cohort of 90 828 participants (7111 cases), including CELSR2-SORT1, NLRP6, and SMC2. primus in englishWebFeb 23, 2024 · PRS-based phenome-wide association studies (PheWAS) have become an increasingly common method to identify different factors associated with the genetic risk of a complex disease [16,17,18,19]. primus industrial corporation

"WebJun 30, 2024 · To fill this gap, we conducted a phenome-wide association study (PheWAS), a summary statistics-based genotype-to-phenotype approach [20, 21], to assess systematically the sex-specific associations of genetically mimicking statins with a wide range of conditions and related phenotypes, using the largest available genome-wide … " - Phenome-wide association study

Phenome-wide association study

Genetically Downregulated Interleukin-6 Signaling Is Associated …

WebJul 13, 2024 · Results. We identified 14 independent loci associated (P < 5 × 10 −8) with estradiol levels in males, of which 1 (CYP3A7) was genome-wide and 7 nominally (P < 0.05) significant in females.In addition, 1 female-specific locus was identified. Most loci contain functionally relevant genes that have not been discussed in relation to estradiol levels in … WebAug 17, 2024 · The factors included in the PheWAS consisted of 10 broad categories (containing 4171 variables), which were 1) sociodemographic, 2) physical measures, 3) lifestyle and environment, 4) health conditions, 5) mental health, 6) medications and operations, 7) cognitive function, 8) sex-specific factors, 9) employment, and 10) early-life …

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WebAug 24, 2024 · We performed a phenome-wide association study (PheWAS) to explore the correlations between imaging phenotypes and 11 categories of non-imaging phenotypes … WebOct 16, 2024 · Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug development through elucidating mechanisms of action, identifying …

WebAbstract Phenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic … WebFeb 23, 2024 · The phenome-wide association study (PheWAS) is a method that enables a ‘reverse genetics’ experiment to be applied to human subjects (Abstract Figure). PheWAS takes advantage of increasingly large sets of human genetic variation coupled to dense phenotypic information often from electronic health records (EHRs) to analyse genotype ...

WebPhenome-wide association studies (PheWAS) invert the idea of a GWAS by searching for phenotypes associated with specific SNVs across the range of thousands of human … WebJun 24, 2024 · To determine the replicability of MAV associations, we compare disease-linked variants with phenome-wide association study (PheWAS) data in the UK Biobank, the largest collection of clinical health records globally. By extension with microbiome by genome-wide association data and gene expression patterns, this framework may …

WebPhenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review aims …

WebApr 12, 2024 · Previous genome-wide association studies (GWASs) investigated single nucleotide polymorphisms (SNPs) that influence the antibody responses against VZV … play the weather for tomorrowWebJan 1, 2024 · Phenome-wide association studies (PheWAS) invert the idea of a GWAS by searching for phenotypes associated with specific SNVs across the range of thousands of human phenotypes, or the “phenome” ( Figure ). Analogous to GWAS, PheWAS have shown that specific genetic variations may be associated with multiple conditions and traits. play the weather todayWebJan 19, 2024 · Previous phenome-wide association studies (PheWAS) for this region demonstrated that HLA association patterns to the phenome have both population-specific and population-shared components. We performed MHC PheWAS in the Korean population by analyzing associations between phenotypes and genetic variants in the MHC region … play the way you look tonightWebApr 11, 2024 · We performed a phenome-wide association study of the index variants with 58 diseases, serum biomarkers, and physiological measurements, among 257 231 … play the webbieWebNov 23, 2024 · Here, we present a phenome-wide association study (PheWAS) approach to systematically explore the phenotypic expressivity of common and rare alleles in genes associated with four well-described syndromic diseases (Alagille (AS), Marfan (MS), DiGeorge (DS), and Noonan (NS) syndromes) in the general population. play the websiteWebApr 12, 2024 · Previous genome-wide association studies (GWASs) investigated single nucleotide polymorphisms (SNPs) that influence the antibody responses against VZV infections. ... Our phenome-wide MR study found anti-VZV IgG to be a causal risk factor of 22 traits, which helped gain new insights into the causal roles of VZV-specific immunity in … play the weather channelWebSep 8, 2024 · Hence, this study aimed to explore the associations between known genetic determinants of the human gut microbiome and the presence of health and its determinants (absence of disease, vital and... play the weather song